Go beyond the database with
InstaNovo and InstaNovo+
Groundbreaking Al for unconditional, reliable discovery in de novo peptide sequence modelling
InstaNovo and InstaNovo+
are redefining AI-driven de novo peptide sequencing
Compared to traditional database searches, InstaNovo increases novel peptide discovery by 34% and achieves an average peptide accuracy of 52% across eight biological datasets. When used together, InstaNovo and InstaNovo+ outperform other de novo sequencing models, identifying 42% more Peptide Spectrum Matches (PSMs).
Developed in collaboration between
&
InstaNovo
InstaNovo is an advanced transformer model for de novo peptide sequencing, translating mass spectra into accurate peptide sequences without relying on a reference database. By directly interpreting fragment ion peaks, InstaNovo enables a more comprehensive analysis of proteomes, including novel proteins and modifications, expanding peptide discovery beyond known sequences.
InstaNovo +
Building on InstaNovo’s predictions, InstaNovo+ refines peptide sequences through an iterative diffusion model. By detecting and correcting errors step-by-step, InstaNovo+ significantly improves prediction accuracy and expands peptide identification, achieving lower false discovery rates and uncovering more novel peptides.
Accelerate progress in biomedicines, drug development, and beyond with AI-powered sequencing at your fingertips
The InstaNovo app provides seamless access to these powerful algorithms-eliminating technical barriers so research can focus on discovery, not implementation.
Try InstaNovo
InstaNovo and InstaNovo+
outperform de novo sequencing tools
Delivering more peptide spectrum matches, near-complete antibody light chain coverage, and an 8-fold boost in novel peptide discovery.
Unconditional
Generate meaningful peptide sequences from unknown samples—no reference database needed.
Reliable
Achieve reliable accuracy in de novo peptide sequencing with diffusion-based Al
Discovery
Expand proteomics research by uncovering novel peptides.
Enhancing peptide sequencing with AI
Diffusion-based AI could introduce a new era of peptide sequencing with InstaNovo and InstaNovo+. AI is revolutionising proteomics and has the potential to unlock new frontiers in targeted healthcare and biomedical research. At the heart of this is peptide sequencing, an essential process for understanding proteins and their role in biological systems.
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Uncover the science
Dive into our research paper to discover the architecture, training process, and breakthroughs that power InstaNovo and InstaNovo+.
Read the paper on Nature Machine Intelligence
Explore our open-source code, contribute to the research, and help enable efficient AI-powered peptide sequencing.
View Code